Recent research published in Nucleic Acids Research has uncovered a novel role for small nucleolar RNAs (snoRNAs) in the transcriptional regulation of the anti-viral response. Here, the Visa group at the Department of Molecular Biosciences, Wenner-Gren Institute (MBW) at Stockholm University, in collaboration with researchers from various Swedish universities, has demonstrated that snoRNAs also participate in the regulating chromatin accessibility to influence gene transcription profiles.