In this project, we aim to identify the genetic determinants of low-level antibiotic resistance in clinically relevant bacterial pathogens by using several different custom-designed antibiotic biosensors to measure single-cell antibiotic uptake in real time.
Many pharmaceutical drugs are known to alter bacterial physiology and influence the efficacy of clinically important antibiotics. In this project, we aim identify novel antibiotic-drug interactions and determine their underlying molecular mechanisms.
