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Melanie Leboeuf

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Contact

Name and title: Melanie Leboeuf

melanie.leboeuf@dbb.su.se

Orcid

0000-0003-0033-7159

Workplace: Department of Biochemistry and Biophysics

Visiting address

Svante Arrhenius väg 16

Postal address

Institutionen för biokemi och biofysik

106 91 Stockholm

Research group

Eva Hedlund's research group

We are focused on understanding mechanisms of selective neuronal vulnerability and resilience in neurodegenerative diseases, with particular emphasis on the lethal motor neuron disease amyotrophic lateral sclerosis (ALS).

About me

I am a Postdoctoral researcher in Eva Hedlund’s lab. During my PhD I have been studying the role of EN1 homeoprotein on mice spinal motoneurons where it acts as a neurotrophic agent. I’ve been exploring the use of EN1 as a therapeutic homeoprotein in the lethal motor neuron disease ALS. I am currently investigating the mechanisms of selective neuronal vulnerability and resilience seen in ALS using neurons specified from human-induced pluripotent stem cells (iPSCs) where disease-causing mutations have been introduced. The lab developed the LCM-seq and Axon-seq methods to unravel motor neuron diversity in response to disease to discover mechanisms that can be targeted by different approaches to render neurons more resistant.

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