15 credits cr.
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The field of high-resolution structural biochemistry has a great impact on our understanding of life at the molecular level.
Note! Information on how teaching will be carried out will be published on kemi.su.se .
The field dealing with protein structure at atomic resolution, structural biochemistry, has had a great impact on our understanding of the details in important processes that occur with high precision in the cell.
This course deals with concepts in structural biochemistry, both in terms of understanding the most important protein structures on a molecular level, as well as the most important techniques for determining three-dimensional structure at atomic resolution.
The important relationship between structure and function is illustrated with examples of how three-dimensional structures have provided us with molecular details of important reactions in the cell. The following main techniques for determining protein structure at atomic resolution are covered:
- X-ray crystallography
- Electron microscopy
- Nuclear magnetic resonance.
This course is intended for students intrested in
- Understanding how macromolecular structures are determined
- Knowing how to examine and interpret protein and nucleic acid structures
- Understanding how structure relates to function
- Making the pretty pictures you see in journals
- Seeing how structural information can be used to guide drug design, mutagenesis and functional studies
The course includes both theoretical and practical work.
The course is composed of
- Group exercises
The course is assed through a written exam and written individual lab reports.
ScheduleThe schedule will be available no later than one month before the start of the course. We do not recommend print-outs as changes can occur. At the start of the course, your department will advise where you can find your schedule during the course.
Schedule from fall semester 2019 presented for reference
Course literatureNote that the course literature can be changed up to two months before the start of the course.
Course litterature presented on this page