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Structural Biochemistry

The field of high-resolution structural biochemistry has a great impact on our understanding of life at the molecular level.

Picture of protein with inhibitor
An inhibitor, in sticks, bound to the active site of a protein. Hydrogen bonds between the inhibitor and the surrounding amino acid residues of the protein can be seen as dashed lines.

Note! Information on how teaching will be carried out will be published on .

The field dealing with protein structure at atomic resolution, structural biochemistry, has had a great impact on our understanding of the details in important processes that occur with high precision in the cell.

This course deals with concepts in structural biochemistry, both in terms of understanding the most important protein structures on a molecular level, as well as the most important techniques for determining three-dimensional structure at atomic resolution.

The important relationship between structure and function is illustrated with examples of how three-dimensional structures have provided us with molecular details of important reactions in the cell. The following main techniques for determining protein structure at atomic resolution are covered:

  • X-ray crystallography
  • Electron microscopy
  • Nuclear magnetic resonance.
  • Course structure

    This course is intended for students intrested in

    • Understanding how macromolecular structures are determined
    • Knowing how to examine and interpret protein and nucleic acid structures
    • Understanding how structure relates to function
    • Making the pretty pictures you see in journals
    • Seeing how structural information can be used to guide drug design, mutagenesis and functional studies

    The course includes both theoretical and practical work.

    Teaching format

    The course is composed of

    • Lectures
    • Labs
    • Seminars
    • Group exercises
    • Presentations



    The course is assed through a written exam and written individual lab reports.


    Ville Kaila


  • Schedule

    The schedule will be available no later than one month before the start of the course. We do not recommend print-outs as changes can occur. At the start of the course, your department will advise where you can find your schedule during the course.

    Schedule from fall semester 2019 presented for reference

  • Course literature

    Note that the course literature can be changed up to two months before the start of the course.

    Course litterature presented on this page

  • Contact

    Course coordinator:

    Ville Kaila


    Chemistry Section & Student Affairs Office:

    Office:        Chemical Practice Laboratory M345