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Structural Biochemistry

  • 15 credits

The field of high-resolution structural biochemistry has a great impact on our understanding of life at the molecular level.

Picture of protein with inhibitor
Inhibitor, in sticks, bound to the active site showing the hydrogen bonds between the inhibitor and the surrounding amino acid residues of the protein

The field dealing with protein structure at atomic resolution, structural biochemistry, has had a great impact on our understanding of the details in important processes that occur with high precision in the cell.

This course deals with concepts in structural biochemistry, both in terms of understanding the most important protein structures on a molecular level, as well as the most important techniques for determining three-dimensional structure at atomic resolution.

The important relationship between structure and function is illustrated with examples of how three-dimensional structures have provided us with molecular details of important reactions in the cell. The following main techniques for determining protein structure at atomic resolution are covered:

  • X-ray crystallography
  • Electron microscopy
  • Nuclear magnetic resonance.
  • Course structure

    This course is intended for students intrested in

    • Understanding how macromolecular structures are determined
    • Knowing how to examine and interpret protein and nucleic acid structures
    • Understanding how structure relates to function
    • Making the pretty pictures you see in journals
    • Seeing how structural information can be used to guide drug design, mutagenesis and functional studies

    The course includes both theoretical and practical work.

    Teaching format

    The course is composed of

    • Lectures
    • Labs
    • Seminars
    • Group exercises
    • Presentations

     

    Assessment

    The course is assed through a written exam and written individual lab reports.

    Examiner

    Ville Kaila

    E-mail: ville.kaila@dbb.su.se

  • Schedule

    This is a preliminary schedule and is subject to continuous change. For this reason, we do not recommend print-outs. At the start of the course, your institution will advise where you can find your schedule during the course.

    Schedule from fall semester 2019 presented for reference

  • Course literature

    Note that the course literature can be changed up to two months before the start of the course.

    Course litterature presented on this page

    http://stenhserv.dbb.su.se/SB/Welcome.html

  • Contact

    Course responsible:

    Ville Kaila

    E-mail:      ville.kaila@dbb.su.se

    Chemistry Section & Student Affairs Office:

    Office:        Chemical Practice Laboratory M345
    E-mail:       exp@kol.su.se

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