Advanced Organic Synthesis
15 credits cr.
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The advanced course in organic synthesis provides a deep understanding of the reactivity and properties of organic compounds.
Note! Information on how teaching will be carried out will be published on kemi.su.se .
The advanced course in organic synthesis provides a deep understanding of the reactivity and properties of organic compounds, and covers modern synthetic methods, stereoselective synthesis and mechanistic understanding. The lab course is advanced, including a multi-step synthesis of a complex organic compound. The lab work is done individually, with several full days in the lab each week.
The course covers detailed studies in synthetic organic chemistry.
- Synthetic methods to produce organic compounds containing the most common reactive groups.
- Reactions with several steps and principles of stereoselective synthesis.
- Reaction mechanisms. Properties and reactivity of organic compounds, based on empirical facts and theoretical calculations.
- Organometallic chemistry and use of organometallic catalysts in organic synthesis.
The laboratory course has emphasis on planning and performing synthetic work including modern synthetic techniques and multistep syntheses.
- Plan and independently perform advanced synthetic lab work
- Understand the importance of safety rules and make risk analyses of planned reactions
- Use SciFinder to search for scientific literature
- Utilize experimental sections in scientific literature to run reactions
- Setup advanced laboratory equipment based on descriptions in scientific literature
- Analyze results using NMR and other techniques
- Critically analyze own and other results – which conclusions can be drawn
- Write detailed and scientifically correct lab book and lab reports
- Understand the importance of scientific ethics and how to avoid plagiarism
- Plan and give scientific oral presentations, answer scientific questions
- Ask scientific questions at fellow student presentations
Theory 7.5 ECTS
Laboratory exercises 7.5 ECTS
The education consists of
- practical laboratory work.
Participation in the practical laboratory work, presentations and thereby associated group teaching is compulsory.
It is expected that the student after taking the course will be able to:
- Solve more advanced organic chemistry problems based on a mechanistic way of thinking.
- Suggest synthetic methods to solve organic chemistry problems, with application of simple retrosynthetic analysis.
- Analyze organic reactions concerning the stereochemical outcome.
- Solve basic organometallic problems.
- Perform more advanced organic chemistry reactions including multistep syntheses.
What to expect, full time studies in organic chemistry
Full time studies correspond to an average of 40 hours weekly, that include:
- laboratory experiments
- laboratory report preparation.
It is important to learn how to manage your time during courses like this. The expected work load may vary between weeks. You may also have free time in the middle of the day, but occasionally need to stay late in the lab to finish onging experiments.
Students will be evaluated based on their theoretical knowledge in a written exam as well as their performance in the lab.
The lab grade is decided based on performance in the following:
- Understanding of written and oral instructions
- Experimental skills
- Interpretation, analysis and understanding of results
- Time planning
- Oral presentations
- Lab reports
- Practical lab exam
- Theoretical lab exam
Telephone: 08-16 27 20
Office: Arrhenius laboratory A619
ScheduleThe schedule will be available no later than one month before the start of the course. We do not recommend print-outs as changes can occur. At the start of the course, your department will advise where you can find your schedule during the course.
Note that the course literature can be changed up to two months before the start of the course.
Organic Chemistry 2nd Ed; Clayden, Greeves and Warren, Oxford University Press, 2012
Lecture handouts and notes.