Grainy head

Grainy head (grh), is a phylogenetically conserved transcription factor. In grh mutants, the apical epithelial cell membrane is overgrown resulting in overgrown airway tubes. Except for its developmental function, Grh emerged as a major regulator of epidermal wound healing in vertebrates and flies. A major focus of our work is the functional analysis Grh target genes, which we recently identified by ChIP-seq. We are exploring their function in epithelial wound healing and airway tube size control.