This course in organic chemistry illustrates and provides the tools necessary for deducing the three-dimensional structure of organic compounds in solution. Through a combination of NMR spectroscopy and molecular modeling, the structural properties of organic compounds including carbohydrates, peptides and nucleotides, are investigated. In addition, other bioorganic compounds like steroids, terpenes and pharmaceutically active compounds are studied.
The theoretical part of the course is focused on providing the student with the proper knowledge necessary for planning, execute and evaluate spectroscopic experiments. The main spectroscopic method used in the course is nuclear magnetic resonance spectroscopy (NMR). In the laboratory exercises the students learn how to perform and evaluate advanced NMR methods such as various 2D-correlation spectroscopy experiments. In addition, computer-based calculations like molecular modeling and molecular dynamic simulations are used for conformational analysis of organic compounds.