DBB Researcher receives SFSG funding to develop new methods in single-cell epigenomics

Dr Marek Bartosovic, researcher at the Department of Biochemistry and Biophysics, has received Swedish Foundations’ Starting Grant for research that will gain new insights into both normal human brain development and into what happens when it goes wrong and neurodevelopmental disorders occur.

Marek Bartosovic

Cells in our bodies can perform very different functions, but all share the same genetic information. This genetic information is inherited from our parents in form of DNA. During the formation of the human body genes encoded in DNA are constantly switched on and off, and it is extremely important that this happens precisely at the right place and at the right time. This is ensured through histone proteins binding to the DNA.

Dr Marek Bartosovic and his research group have recently developed new technology to measure histone modifications with unprecedented accuracy in individual cells, thousands of cells at the same time. Thanks to this kind of measurement, it is now possible to better describe the regulation of how genes are turned on and off in highly dynamic and complex organs such as the brain. 

In this project the technology will be further developed to enable a more detailed description of the regulation of genes during brain development. Dr Bartosovic and his research group expect to be able to better describe normal human brain development at the gene and molecule level. They will also investigate the molecular and cellular changes that lead to neuropsychiatric and neurodevelopmental disorders such as autism spectrum disorder or various forms of intellectual disabilities.

Read more about SFSG and Dr Bartosovic as grant fellow here

Read more about Olle Engkvists stiftelse here