Claes Andréasson

Assistent Professor Claes Andréasson

 

Stockholm University
The Wenner-Gren Institute
Cell Biology
Svante Arrheniusväg 20B,  room F452
106 91 Stockholm
Sweden

Phone: 0046 8 16 42 02
Fax: 00 46 8 15 98 37
Email:claes.andreasson@wgi.su.se

 

Hsp70 molecular chaperones in the cell

My research is primarily focused on understanding the mechanisms underlying protein folding in the eukaryotic cell. Hence, how the cell maintains proper protein folding capacity to avoid disease states caused by misfolded proteins. This protein homeostasis, or proteostasis, is based on the expression of specialized molecular chaperones that aid in protein folding by binding the unfolded protein clients and helping them to fold.
 

Selected publications

Omnus DJ, Pfirrmann T, Andréasson C, Ljungdahl PO.
A phosphodegron controls nutrient-induced proteasomal activation of the signaling protease Ssy5.
Mol Biol Cell. 2011 Aug 1;22(15):2754-65. Epub 2011 Jun 8.
PMID: 21653827

Andréasson C., Fiaux J., Rampelt H., and Bukau B. (2010) The endoplasmic reticulum Grp170 acts as a nucleotide exchange factor of Hsp70 via a mechanism similar to that of the cytosolic Hsp110 J Biol Chem. 285:12445-53.

Andréasson C., Fiaux J., Rampelt H., Druffel S. and Bukau B. (2008) Insights into the structural dynamics of the Hsp110-Hsp70 interaction reveal the mechanism for nucleotide exchange activity Proc Nat Acad Sci. 105:16519-24

Sadlish H., Rampelt H., Shorter J., Wegrzyn R.D., Andréasson C., Lindquist S. and Bukau B. (2008) Hsp110 chaperones regulate prion formation and propagation in S. cerevisiae by two discrete activities. PloS ONE. 3:e1763

Andréasson C., Fiaux J., Rampelt H., Mayer M.P. and Bukau B. (2008) Hsp110 is a nucleotide-activated exchange factor for Hsp70. J Biol Chem. 283:8877-84.

 

Contacts

Cell Biology  Per Ljungdahl, Phone: +46 8 16 41 01

Developmental Biology Christos Samakovlis, Phone: + 46 8 16 15 64

Immunology Marita Troye Blomberg, Phone: + 46 8 16 41 64

Physiology Barbara Cannon, Phone:+ 46 8 16 41 20


 

Imaging Facility, IFSU

Zeiss LSM 780

Vacancies