Klavs Berzins

Professor Klavs Berzins

Stockholm University
The Wenner-Gren Institute
Svante Arrheniusväg 20B, F568
106 91 Stockholm

Phone: 00 46 8 16 41 70
Fax: 00 46 8 612 95 42



Evaluation of P. falciparum antigen Pf332 as a target for parasite neutralizing immune responses


This project is based on the P. falciparum antigen Pf332, which we identified in 1989 together with Mattei et al. at the Pasteur Institute in Paris. Subsequent data on Pf332, obtained mainly by our groups by laboratory experiments and epidemiological investigations, indicate that the antigen stands out as an attractive target for vaccine development. However, the previous research on Pf332 has involved mainly a 157 amino acids long fragment (EB200) of the antigen; the complete 5506 a.a. sequence became recently available from the sequencing of the P. falciparum genome.

Selected publications

Characterization of the Duffy-binding like domain of Plasmodium falciparum blood-stage antigen 332.
Malaria Res. Treatm. doi:10.4061/2011/671439.
Nilsson, S., Moll, K., Angeletti, D., Albrecht, L., Kursula, I, Jiang, N., Sun, X., Berzins, K., Wahlgren, M.,Chen, Q. (2011) 

Associations of multi-locus polymorphisms in an immune network with susceptibility to uncomplicated Plasmodium falciparum malaria in Daraweesh village, Eastern Sudan.
Giha HA, Nasr A, Iriemenam NC, Troye-Blomberg M, Berzins K, Pandey JP, Elghazali G.
Infect Genet Evol. 2011 Jun 26. [Epub ahead of print]
PMID: 21729768

Cytokine gene haplotypes with a potential effect on susceptibility to malaria in sympatric ethnic groups in Mali.

Israelsson E, Maiga B, Kearsley S, Dolo A, Homann MV, Doumbo OK, Troye-Blomberg M, Tornvall P, Berzins K.

Infect Genet Evol. 2011 Jun 25. [Epub ahead of print]11,1608-1615.
PMID: 21708291

Pattern of Pre-existing IgG Subclass Responses to a Panel of Asexual Stage Malaria Antigens Reported During the Lengthy Dry Season in Daraweesh, Sudan.

Nasr AA, Iriemenam NC, Troye-Blomberg M, Arnot D, Theander TG, Berzins K, Giha HA, Elghazali G.
Scand J Immunol. 2011 Oct;74(4):390-396. doi: 10.1111/j.1365-3083.2011.02585.x.
PMID: 21645028

Antibodies to the Plasmodium falciparum rhoptry protein RAP-2/RSP-2 in relation to anaemia in Cameroonian children.

Awah N, Balogun H, Achidi E, Mariuba LA, Nogueira PA, Orlandi P, Troye-Blomberg M, Gysin J, Berzins K.Parasite Immunol. 2011 Feb;33(2):104-15. doi: 10.1111/j.1365-3024.2010.01259.x.PMID: 21226723


Cell Biology  Per Ljungdahl, Phone: +46 8 16 41 01

Developmental Biology Christos Samakovlis, Phone: + 46 8 16 15 64

Immunology Marita Troye Blomberg, Phone: + 46 8 16 41 64

Physiology Barbara Cannon, Phone:+ 46 8 16 41 20


Imaging Facility, IFSU

Zeiss LSM 780