Speaker: Pierre-Yves Mantel (PhD), University of Fribourg, Switzerland; Harvard School of Public Health, USA

Title: Extracellular vesicles in the regulation of host-pathogen interactions during malaria: a matter of cellular communication



Extracellular vesicles (EVs), including exosomes and microvesicles, are small membrane vesicles derived from multivesicular bodies or from the plasma membrane. EVs play important roles in intercellular communication, both locally and systemically, as they transfer their contents including; proteins, lipids and RNAs between cells. EVs are involved in numerous physiological processes and vesicles from both non-immune and immune cells have important roles in immune regulation. We have showed that Plasmodium falciparum infected red blood cells (iRBCs) release vesicles, which not only regulate parasite development but also mediate host-pathogen interactions. EVs contain RBC-derived miRNAs that regulate gene expression in the recipient cells including endothelial cells and neutrophils. We are investigating the contribution of EVs in the regulation of the pathogenesis during malaria. Our data suggest that miR451a, contained in EVs, is an important regulator of the immune response to the malaria parasites.

Host: Johan Ankarklev